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| 1st(1st leg) | Royal Pari | - | Real Potosí | 2:1 (1:1) | ||
| 2nd (2nd leg) | Real Potosí | - | Royal Pari | 4:3 (1:0, 3:0) pso | ||
| 1st(1st leg): 19/05/2018 20:00 | 2nd (2nd leg): 26/05/2018 22:15 | Winner: Real Potosí | ||||
| 1st(1st leg) | CD Guabirá | - | Sport Boys Warnes | 2:2 (2:1) | ||
| 2nd (2nd leg) | Sport Boys Warnes | - | CD Guabirá | 4:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 20/05/2018 20:00 | 2nd (2nd leg): 27/05/2018 00:30 | Winner: CD Guabirá | ||||
