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| 1st(1st leg) | Jorge Wilstermann | - | Blooming | 3:0 (2:0) | ||
| 2nd (2nd leg) | Blooming | - | Jorge Wilstermann | 1:3 (1:3) | ||
| 1st(1st leg): 06/05/2018 20:00 | 2nd (2nd leg): 14/05/2018 00:30 | Winner: Jorge Wilstermann | ||||
| 1st(1st leg) | Oriente Petrolero | - | The Strongest | 0:1 (0:0) | ||
| 2nd (2nd leg) | The Strongest | - | Oriente Petrolero | 5:1 (4:0) | ||
| 1st(1st leg): 06/05/2018 20:00 | 2nd (2nd leg): 12/05/2018 20:00 | Winner: The Strongest | ||||
| 1st(1st leg) | Nacional Potosí | - | Bolívar | 1:2 (1:1) | ||
| 2nd (2nd leg) | Bolívar | - | Nacional Potosí | 1:0 (0:0) | ||
| 1st(1st leg): 06/05/2018 22:15 | 2nd (2nd leg): 13/05/2018 01:45 | Winner: Bolívar | ||||
| 1st(1st leg) | Destroyers | - | San José | 1:0 (1:0) | ||
| 2nd (2nd leg) | San José | - | Destroyers | 4:2 (4:0, 8:0) pso | ||
| 1st(1st leg): 07/05/2018 00:30 | 2nd (2nd leg): 12/05/2018 22:15 | Winner: San José | ||||
