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| 1st(1st leg) | Destroyers | - | Nueva Cliza | 2:0 | ||
| 2nd (2nd leg) | Nueva Cliza | - | Destroyers | 1:0 | ||
| 1st(1st leg): 04/10/2022 20:00 | 2nd (2nd leg): 07/10/2022 20:00 | Winner: Destroyers | ||||
| 1st(1st leg) | Deportivo FATIC | - | Oruro Royal | 0:0 | ||
| 2nd (2nd leg) | Oruro Royal | - | Deportivo FATIC | 1:3 | ||
| 1st(1st leg): 05/10/2022 18:00 | 2nd (2nd leg): 08/10/2022 18:00 | Winner: Deportivo FATIC | ||||
| 1st(1st leg) | Deportivo JUVA | - | Cervecería Nacional | 2:2 | ||
| 2nd (2nd leg) | Cervecería Nacional | - | Deportivo JUVA | 0:2 | ||
| 1st(1st leg): 05/10/2022 20:00 | 2nd (2nd leg): 09/10/2022 20:00 | Winner: Deportivo JUVA | ||||
| 1st(1st leg) | Stormers de Sucre | - | Escuela Enrique Happ | 1:1 | ||
| 2nd (2nd leg) | Escuela Enrique Happ | - | Stormers de Sucre | 4:3 aet | ||
| 1st(1st leg): 05/10/2022 20:00 | 2nd (2nd leg): 08/10/2022 20:00 | Winner: Escuela Enrique Happ | ||||
| 1st(1st leg) | Mariscal Sucre | - | Sur-Car | 2:2 | ||
| 2nd (2nd leg) | Sur-Car | - | Mariscal Sucre | 4:0 | ||
| 1st(1st leg): 05/10/2022 22:00 | 2nd (2nd leg): 09/10/2022 20:00 | Winner: Sur-Car | ||||
| 1st(1st leg) | ABB | - | Libertad Gran Mamoré | 2:2 (1:0) | ||
| 2nd (2nd leg) | Libertad Gran Mamoré | - | ABB | 4:0 | ||
| 1st(1st leg): 06/10/2022 18:00 | 2nd (2nd leg): 09/10/2022 20:00 | Winner: Libertad Gran Mamoré | ||||
| 1st(1st leg) | García Agreda | - | 24 de Septiembre de Santa Cruz | 0:0 (0:0) | ||
| 2nd (2nd leg) | 24 de Septiembre de Santa Cruz | - | García Agreda | 3:2 | ||
| 1st(1st leg): 06/10/2022 20:00 | 2nd (2nd leg): 10/10/2022 19:00 | Winner: 24 de Septiembre de Santa Cruz | ||||
| 1st(1st leg) | Vaca Díez | - | Bermejo | 3:0 | ||
| 2nd (2nd leg) | Bermejo | - | Vaca Díez | 0:3 | ||
| 1st(1st leg): 06/10/2022 22:00 | 2nd (2nd leg): 09/10/2022 20:00 | Winner: Vaca Díez | ||||
