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| 10/03/2006 | 19:30 | Sint-Truidense VV | - | RSC Anderlecht | 3:0 (0:0) | |
| 11/03/2006 | 17:00 | KRC Genk | - | Germinal Beerschot | 1:0 (0:0) | |
| 19:00 | KSV Roeselare | - | SV Zulte Waregem | 0:3 (0:1) | ||
| 19:00 | Club Brugge KV | - | Sporting Charleroi | 2:1 (1:1) | ||
| 19:00 | KSK Beveren | - | KVC Westerlo | 4:1 (1:0) | ||
| 19:00 | Lierse SK | - | KAA Gent | 1:3 (1:1) | ||
| 19:00 | FC Brussels | - | RAA La Louviére | 0:0 (0:0) | ||
| 19:00 | Excelsior Mouscron | - | Cercle Brugge | 6:0 (2:0) | ||
| 12/03/2006 | 17:00 | Sporting Lokeren | - | Standard Liège | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 26 | 15 | 7 | 4 | 54:25 | 29 | 52 |
| 2 |
|
Standard Liège | 26 | 15 | 6 | 5 | 45:23 | 22 | 51 |
| 3 |
|
Club Brugge KV | 26 | 14 | 8 | 4 | 41:25 | 16 | 50 |
| 4 |
|
SV Zulte Waregem | 26 | 14 | 5 | 7 | 46:34 | 12 | 47 |
| 5 |
|
KRC Genk | 26 | 12 | 8 | 6 | 44:30 | 14 | 44 |
| 6 |
|
KAA Gent | 26 | 12 | 5 | 9 | 35:30 | 5 | 41 |
| 7 |
|
Sporting Lokeren | 26 | 10 | 9 | 7 | 37:34 | 3 | 39 |
| 8 |
|
KVC Westerlo | 26 | 11 | 5 | 10 | 35:34 | 1 | 38 |
| 9 |
|
FC Brussels | 26 | 8 | 10 | 8 | 25:25 | 0 | 34 |
| 10 |
|
Sporting Charleroi | 26 | 9 | 7 | 10 | 28:31 | -3 | 34 |
| 11 |
|
KSV Roeselare | 26 | 8 | 8 | 10 | 39:36 | 3 | 32 |
| 12 |
|
Germinal Beerschot | 26 | 9 | 4 | 13 | 37:41 | -4 | 31 |
| 13 |
|
Excelsior Mouscron | 26 | 8 | 4 | 14 | 37:36 | 1 | 28 |
| 14 |
|
Sint-Truidense VV | 26 | 6 | 8 | 12 | 29:37 | -8 | 26 |
| 15 |
|
Cercle Brugge | 26 | 7 | 5 | 14 | 30:55 | -25 | 26 |
| 16 |
|
KSK Beveren | 26 | 7 | 3 | 16 | 30:45 | -15 | 24 |
| 17 |
|
RAA La Louviére | 26 | 4 | 11 | 11 | 21:45 | -24 | 23 |
| 18 |
|
Lierse SK | 26 | 5 | 7 | 14 | 17:44 | -27 | 22 |
