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| 03/02/2006 | 19:30 | Club Brugge KV | - | Lierse SK | 3:1 (1:0) | |
| 04/02/2006 | 17:00 | RSC Anderlecht | - | KRC Genk | 4:1 (2:1) | |
| 19:00 | SV Zulte Waregem | - | Cercle Brugge | 3:1 (0:0) | ||
| 19:00 | KVC Westerlo | - | Excelsior Mouscron | 0:5 (0:1) | ||
| 19:00 | Sporting Charleroi | - | FC Brussels | 1:0 (0:0) | ||
| 19:00 | KSK Beveren | - | Sint-Truidense VV | 1:1 (1:1) | ||
| 19:00 | Sporting Lokeren | - | KSV Roeselare | 2:2 (0:2) | ||
| 19:00 | KAA Gent | - | Germinal Beerschot | 2:1 (2:1) | ||
| 22/02/2006 | 19:30 | Standard Liège | - | RAA La Louviére | 1:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Brugge KV | 21 | 12 | 6 | 3 | 35:19 | 16 | 42 |
| 2 |
|
RSC Anderlecht | 21 | 11 | 7 | 3 | 46:22 | 24 | 40 |
| 3 |
|
Standard Liège | 21 | 12 | 4 | 5 | 32:20 | 12 | 40 |
| 4 |
|
SV Zulte Waregem | 21 | 11 | 4 | 6 | 41:32 | 9 | 37 |
| 5 |
|
KRC Genk | 21 | 9 | 7 | 5 | 35:27 | 8 | 34 |
| 6 |
|
KAA Gent | 21 | 10 | 4 | 7 | 29:25 | 4 | 34 |
| 7 |
|
KVC Westerlo | 21 | 9 | 5 | 7 | 28:24 | 4 | 32 |
| 8 |
|
Sporting Lokeren | 21 | 8 | 8 | 5 | 31:29 | 2 | 32 |
| 9 |
|
Sporting Charleroi | 21 | 8 | 6 | 7 | 22:25 | -3 | 30 |
| 10 |
|
FC Brussels | 21 | 7 | 8 | 6 | 24:22 | 2 | 29 |
| 11 |
|
KSV Roeselare | 21 | 6 | 8 | 7 | 33:27 | 6 | 26 |
| 12 |
|
Germinal Beerschot | 21 | 7 | 3 | 11 | 28:36 | -8 | 24 |
| 13 |
|
Excelsior Mouscron | 21 | 7 | 2 | 12 | 31:34 | -3 | 23 |
| 14 |
|
Cercle Brugge | 21 | 6 | 4 | 11 | 27:36 | -9 | 22 |
| 15 |
|
KSK Beveren | 21 | 6 | 3 | 12 | 25:34 | -9 | 21 |
| 16 |
|
RAA La Louviére | 21 | 4 | 8 | 9 | 20:38 | -18 | 20 |
| 17 |
|
Sint-Truidense VV | 21 | 4 | 6 | 11 | 20:31 | -11 | 18 |
| 18 |
|
Lierse SK | 21 | 2 | 7 | 12 | 11:37 | -26 | 13 |
