 |
 |
|
|
| 1st(1st leg) | KAA Gent | - | Club Brugge KV | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Brugge KV | - | KAA Gent | 0:3 (0:2) | ||
| 1st(1st leg): 02/02/2022 19:45 | 2nd (2nd leg): 02/03/2022 19:45 | Winner: KAA Gent | ||||
| 1st(1st leg) | KAS Eupen | - | RSC Anderlecht | 2:2 (1:1) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | KAS Eupen | 3:1 (2:1) | ||
| 1st(1st leg): 03/02/2022 19:45 | 2nd (2nd leg): 03/03/2022 19:45 | Winner: RSC Anderlecht | ||||
