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| 26/10/2011 | 19:00 | SV Zulte Waregem | - | Standard Liège | 1:2 (0:1) | |
| 19:30 | KV Kortrijk | - | Sint-Truidense VV | 1:0 (0:0) | ||
| 19:30 | KRC Genk | - | Lierse SK | 0:2 (0:1) | ||
| 19:30 | Cercle Brugge | - | Beerschot AC | 0:1 (0:0, 0:0) aet | ||
| 19:30 | RAEC Mons | - | KV Mechelen | 1:0 (0:0) | ||
| 19:30 | Sporting Lokeren | - | KVC Westerlo | 3:1 (1:1) | ||
| 19:30 | RSC Anderlecht | - | Rupel Boom FC | 1:2 (0:1) | ||
| 19:45 | KAA Gent | - | Club Brugge KV | 4:2 (1:3, 4:4, 4:4) pso |
