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| 09/11/2010 | 19:45 | Standard Liège | - | KRC Genk | 2:1 (1:1) | |
| 10/11/2010 | 19:00 | KAA Gent | - | KAS Eupen | 3:1 (1:0) | |
| 19:30 | KV Kortrijk | - | KV Mechelen | 1:2 (0:0) | ||
| 19:30 | R. White Star Woluwe FC | - | Sporting Lokeren | 1:0 (1:0) | ||
| 19:30 | KVC Westerlo | - | RSC Anderlecht | 1:0 (0:0) | ||
| 19:30 | Cercle Brugge | - | Waasland-Beveren | 3:1 (1:0) | ||
| 19:30 | RFC Tournai | - | Lierse SK | 1:4 (0:2) | ||
| 19:30 | Germinal Beerschot | - | Club Brugge KV | 2:1 (0:1) |
