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| 21/08/2010 | 18:00 | RFC Tournai | - | Oud-Heverlee Leuven | 4:3 pso | |
| 18:00 | URS du Centre | - | KFC Sparta Petegem | 1:0 | ||
| 19:00 | RAEC Mons | - | KSV Roeselare | 1:3 aet | ||
| 19:00 | Lommel United | - | RJS Heppignies-Lambusart-Fleurus | 3:0 | ||
| 19:00 | Standaard Wetteren | - | Hoogstraten VV | 2:1 | ||
| 22/08/2010 | 15:00 | CS Visé | - | Excelsior Virton | 0:3 | |
| 15:00 | Eendracht Aalst | - | KSK Ronse | 2:0 | ||
| 15:00 | KRC Mechelen | - | KVV Coxyde | 1:3 | ||
| 15:00 | R. Cappellen FC | - | KV Turnhout | 0:2 | ||
| 15:00 | R. White Star Woluwe FC | - | KFC de Kempen | 4:0 | ||
| 15:00 | KVK Tienen | - | K. Lyra TSV | 3:1 | ||
| 15:00 | Royal Mouscron-Péruwelz | - | KFC Lille | 2:5 pso | ||
| 15:00 | Olsa Brakel | - | KRC Waregem | 1:3 | ||
| 15:00 | Rupel Boom FC | - | KSC Grimbergen | 1:0 | ||
| 15:00 | Waasland-Beveren | - | KSK Heist | 4:2 | ||
| 22/09/2010 | 19:00 | Lutlommel VV | - | Royal Antwerp FC | 2:3 (2:2) |
