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| 1st(1st leg) | VfL Bochum | - | Hamburger SV | 2:1 | ||
| 2nd (2nd leg) | Hamburger SV | - | VfL Bochum | 3:4 pso | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: VfL Bochum | ||||
| 1st(1st leg) | Spandauer SV | - | Hannover 96 | 0:2 | ||
| 2nd (2nd leg) | Hannover 96 | - | Spandauer SV | 2:1 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Hannover 96 | ||||
| 1st(1st leg) | VfR Neumünster | - | OT Bremen | 1:2 | ||
| 2nd (2nd leg) | OT Bremen | - | VfR Neumünster | 3:1 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: OT Bremen | ||||
| 1st(1st leg) | Bor. Mönchengladbach | - | 1. FC Köln | 1:3 | ||
| 2nd (2nd leg) | 1. FC Köln | - | Bor. Mönchengladbach | 6:7 pso | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Bor. Mönchengladbach | ||||
| 1st(1st leg) | FC Ensdorf | - | SG 99 Andernach | 2:0 | ||
| 2nd (2nd leg) | SG 99 Andernach | - | FC Ensdorf | 0:5 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: FC Ensdorf | ||||
| 1st(1st leg) | FC Augsburg | - | Eintracht Frankfurt | 1:3 | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | FC Augsburg | 4:0 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Eintracht Frankfurt | ||||
| 1st(1st leg) | VfB Stuttgart | - | Karlsruher SC | 1:0 | ||
| 2nd (2nd leg) | Karlsruher SC | - | VfB Stuttgart | 0:4 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: VfB Stuttgart | ||||
| 1st(1st leg) | FC 08 Villingen | - | 1. FC Kaiserslautern | 0:7 | ||
| 2nd (2nd leg) | 1. FC Kaiserslautern | - | FC 08 Villingen | 6:2 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: 1. FC Kaiserslautern | ||||
