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| 04/10/2022 | 00:00 | Rosario Central | - | Unión de Santa Fe | 1:1 (0:1) | |
| 18:00 | Aldosivi | - | Barracas Central | 2:0 (0:0) | ||
| 20:30 | Godoy Cruz | - | San Lorenzo | 0:0 (0:0) | ||
| 20:30 | Newell's Old Boys | - | Arsenal de Sarandí | 0:0 (0:0) | ||
| 23:00 | Sarmiento de Junín | - | Tigre | 2:2 (1:2) | ||
| 05/10/2022 | 01:30 | Vélez Sarsfield | - | Banfield | 1:0 (0:0) | |
| 20:30 | Colón de Santa Fe | - | Patronato de Paraná | 1:0 (1:0) | ||
| 23:00 | Atlético Tucumán | - | Platense | 2:1 (2:1) | ||
| 23:00 | Defensa y Justicia | - | Racing Club | 3:3 (2:2) | ||
| 06/10/2022 | 01:30 | Independiente | - | Central Córdoba SdE | 1:2 (0:0) | |
| 01:30 | River Plate | - | Estudiantes | 5:0 (2:0) | ||
| 23:00 | Huracán | - | Talleres de Córdoba | 1:0 (0:0) | ||
| 23:00 | Lanús | - | Argentinos Juniors | 0:4 (0:2) | ||
| 20/10/2022 | 19:00 | Gimnasia de La Plata | - | Boca Juniors | 1:2 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors | 23 | 14 | 3 | 6 | 29:23 | 6 | 45 |
| 2 |
|
Atlético Tucumán | 23 | 12 | 8 | 3 | 29:15 | 14 | 44 |
| 3 |
|
Racing Club | 23 | 11 | 8 | 4 | 35:22 | 13 | 41 |
| 4 |
|
Huracán | 23 | 10 | 10 | 3 | 27:16 | 11 | 40 |
| 5 |
|
River Plate | 23 | 11 | 5 | 7 | 37:18 | 19 | 38 |
| 6 |
|
Gimnasia de La Plata | 23 | 10 | 7 | 6 | 23:15 | 8 | 37 |
| 7 |
|
Argentinos Juniors | 23 | 11 | 3 | 9 | 30:23 | 7 | 36 |
| 8 |
|
Tigre | 23 | 8 | 10 | 5 | 34:26 | 8 | 34 |
| 9 |
|
Godoy Cruz | 23 | 9 | 7 | 7 | 24:23 | 1 | 34 |
| 10 |
|
Newell's Old Boys | 23 | 9 | 6 | 8 | 20:19 | 1 | 33 |
| 11 |
|
San Lorenzo | 23 | 6 | 13 | 4 | 24:21 | 3 | 31 |
| 12 |
|
Patronato de Paraná | 23 | 8 | 7 | 8 | 26:24 | 2 | 31 |
| 13 |
|
Platense | 23 | 7 | 10 | 6 | 20:18 | 2 | 31 |
| 14 |
|
Central Córdoba SdE | 23 | 9 | 4 | 10 | 29:29 | 0 | 31 |
| 15 |
|
Independiente | 23 | 8 | 6 | 9 | 25:25 | 0 | 30 |
| 16 |
|
Sarmiento de Junín | 23 | 8 | 6 | 9 | 24:26 | -2 | 30 |
| 17 |
|
Defensa y Justicia | 23 | 7 | 9 | 7 | 23:25 | -2 | 30 |
| 18 |
|
Unión de Santa Fe | 23 | 7 | 7 | 9 | 25:30 | -5 | 28 |
| 19 |
|
Barracas Central | 23 | 7 | 7 | 9 | 25:32 | -7 | 28 |
| 20 |
|
Estudiantes | 23 | 7 | 6 | 10 | 22:32 | -10 | 27 |
| 21 |
|
Talleres de Córdoba | 23 | 6 | 8 | 9 | 19:21 | -2 | 26 |
| 22 |
|
Banfield | 23 | 6 | 8 | 9 | 22:26 | -4 | 26 |
| 23 |
|
Rosario Central | 23 | 6 | 8 | 9 | 20:25 | -5 | 26 |
| 24 |
|
Colón de Santa Fe | 23 | 6 | 7 | 10 | 20:30 | -10 | 25 |
| 25 |
|
Arsenal de Sarandí | 23 | 4 | 12 | 7 | 21:25 | -4 | 24 |
| 26 |
|
Vélez Sarsfield | 23 | 4 | 10 | 9 | 24:29 | -5 | 22 |
| 27 |
|
Lanús | 23 | 5 | 5 | 13 | 20:34 | -14 | 20 |
| 28 |
|
Aldosivi | 23 | 4 | 4 | 15 | 14:39 | -25 | 16 |
