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| 18/11/2021 | 20:00 | Unión de Santa Fe | - | Defensa y Justicia | 2:3 (2:1) | |
| 22:15 | Patronato de Paraná | - | Lanús | 3:2 (1:2) | ||
| 19/11/2021 | 00:30 | Banfield | - | Aldosivi | 0:2 (0:0) | |
| 20:00 | Estudiantes | - | Huracán | 4:1 (3:1) | ||
| 22:15 | San Lorenzo | - | Gimnasia de La Plata | 0:1 (0:1) | ||
| 20/11/2021 | 00:30 | Argentinos Juniors | - | Godoy Cruz | 0:0 (0:0) | |
| 00:30 | Talleres de Córdoba | - | Vélez Sarsfield | 1:1 (0:0) | ||
| 20:00 | Rosario Central | - | Atlético Tucumán | 3:1 (2:0) | ||
| 22:15 | Boca Juniors | - | Sarmiento de Junín | 2:0 (1:0) | ||
| 21/11/2021 | 00:30 | Central Córdoba SdE | - | Independiente | 1:0 (0:0) | |
| 20:00 | Arsenal de Sarandí | - | Newell's Old Boys | 3:1 (1:0) | ||
| 22:15 | Racing Club | - | Colón de Santa Fe | 1:2 (1:1) | ||
| 22/11/2021 | 00:30 | Platense | - | River Plate | 0:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 21 | 15 | 4 | 2 | 44:13 | 31 | 49 |
| 2 |
|
Talleres de Córdoba | 21 | 12 | 4 | 5 | 31:20 | 11 | 40 |
| 3 |
|
Defensa y Justicia | 21 | 10 | 7 | 4 | 33:20 | 13 | 37 |
| 4 |
|
Boca Juniors | 21 | 10 | 6 | 5 | 26:16 | 10 | 36 |
| 5 |
|
Vélez Sarsfield | 21 | 9 | 8 | 4 | 30:17 | 13 | 35 |
| 6 |
|
Lanús | 21 | 10 | 5 | 6 | 37:33 | 4 | 35 |
| 7 |
|
Colón de Santa Fe | 21 | 10 | 5 | 6 | 21:23 | -2 | 35 |
| 8 |
|
Estudiantes | 21 | 8 | 8 | 5 | 33:23 | 10 | 32 |
| 9 |
|
Independiente | 21 | 8 | 7 | 6 | 22:18 | 4 | 31 |
| 10 |
|
Gimnasia de La Plata | 21 | 8 | 7 | 6 | 18:19 | -1 | 31 |
| 11 |
|
Huracán | 21 | 7 | 8 | 6 | 20:20 | 0 | 29 |
| 12 |
|
Godoy Cruz | 21 | 7 | 6 | 8 | 28:26 | 2 | 27 |
| 13 |
|
Rosario Central | 21 | 8 | 3 | 10 | 30:32 | -2 | 27 |
| 14 |
|
Racing Club | 21 | 6 | 8 | 7 | 19:16 | 3 | 26 |
| 15 |
|
Argentinos Juniors | 21 | 6 | 8 | 7 | 19:20 | -1 | 26 |
| 16 |
|
Unión de Santa Fe | 21 | 7 | 4 | 10 | 25:30 | -5 | 25 |
| 17 |
|
Aldosivi | 21 | 7 | 3 | 11 | 21:33 | -12 | 24 |
| 18 |
|
Platense | 21 | 5 | 8 | 8 | 24:27 | -3 | 23 |
| 19 |
|
Sarmiento de Junín | 21 | 6 | 5 | 10 | 22:28 | -6 | 23 |
| 20 |
|
Patronato de Paraná | 21 | 5 | 8 | 8 | 23:31 | -8 | 23 |
| 21 |
|
Newell's Old Boys | 21 | 6 | 5 | 10 | 21:29 | -8 | 23 |
| 22 |
|
Banfield | 21 | 4 | 9 | 8 | 16:24 | -8 | 21 |
| 23 |
|
Atlético Tucumán | 21 | 5 | 6 | 10 | 21:35 | -14 | 21 |
| 24 |
|
Central Córdoba SdE | 21 | 4 | 8 | 9 | 22:27 | -5 | 20 |
| 25 |
|
San Lorenzo | 21 | 5 | 5 | 11 | 18:28 | -10 | 20 |
| 26 |
|
Arsenal de Sarandí | 21 | 4 | 7 | 10 | 11:27 | -16 | 19 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
