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| 23/07/2021 | 23:00 | Atlético Tucumán | - | Huracán | 1:0 (1:0) | |
| 24/07/2021 | 01:15 | Platense | - | Aldosivi | 0:1 (0:0) | |
| 17:30 | Colón de Santa Fe | - | Lanús | 1:4 (1:1) | ||
| 19:45 | San Lorenzo | - | Central Córdoba SdE | 1:0 (1:0) | ||
| 22:00 | Racing Club | - | Gimnasia de La Plata | 0:0 (0:0) | ||
| 25/07/2021 | 00:15 | Banfield | - | Boca Juniors | 0:0 (0:0) | |
| 17:30 | Patronato de Paraná | - | Sarmiento de Junín | 2:0 (1:0) | ||
| 17:30 | Defensa y Justicia | - | Godoy Cruz | 1:2 (1:0) | ||
| 19:45 | Rosario Central | - | Vélez Sarsfield | 1:0 (0:0) | ||
| 22:00 | River Plate | - | Unión de Santa Fe | 4:0 (2:0) | ||
| 26/07/2021 | 00:15 | Estudiantes | - | Independiente | 0:1 (0:1) | |
| 22:00 | Talleres de Córdoba | - | Arsenal de Sarandí | 2:0 (1:0) | ||
| 27/07/2021 | 00:15 | Argentinos Juniors | - | Newell's Old Boys | 1:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lanús | 2 | 2 | 0 | 0 | 8:3 | 5 | 6 |
| 2 |
|
Patronato de Paraná | 2 | 2 | 0 | 0 | 4:0 | 4 | 6 |
| 3 |
|
Godoy Cruz | 2 | 2 | 0 | 0 | 4:2 | 2 | 6 |
| 4 |
|
San Lorenzo | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
| 5 |
|
Argentinos Juniors | 2 | 1 | 1 | 0 | 1:0 | 1 | 4 |
|
Independiente | 2 | 1 | 1 | 0 | 1:0 | 1 | 4 | |
| 7 |
|
River Plate | 2 | 1 | 0 | 1 | 5:2 | 3 | 3 |
| 8 |
|
Estudiantes | 2 | 1 | 0 | 1 | 3:1 | 2 | 3 |
| 9 |
|
Talleres de Córdoba | 2 | 1 | 0 | 1 | 4:3 | 1 | 3 |
| 10 |
|
Newell's Old Boys | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 |
| 11 |
|
Huracán | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
|
Rosario Central | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 | |
| 13 |
|
Atlético Tucumán | 2 | 1 | 0 | 1 | 3:4 | -1 | 3 |
| 14 |
|
Aldosivi | 2 | 1 | 0 | 1 | 1:2 | -1 | 3 |
| 15 |
|
Colón de Santa Fe | 2 | 1 | 0 | 1 | 3:5 | -2 | 3 |
| 16 |
|
Gimnasia de La Plata | 2 | 0 | 2 | 0 | 2:2 | 0 | 2 |
| 17 |
|
Banfield | 2 | 0 | 2 | 0 | 1:1 | 0 | 2 |
|
Boca Juniors | 2 | 0 | 2 | 0 | 1:1 | 0 | 2 | |
| 19 |
|
Racing Club | 2 | 0 | 2 | 0 | 0:0 | 0 | 2 |
| 20 |
|
Platense | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
| 21 |
|
Central Córdoba SdE | 2 | 0 | 1 | 1 | 1:2 | -1 | 1 |
| 22 |
|
Vélez Sarsfield | 2 | 0 | 1 | 1 | 0:1 | -1 | 1 |
| 23 |
|
Arsenal de Sarandí | 2 | 0 | 1 | 1 | 1:3 | -2 | 1 |
| 24 |
|
Unión de Santa Fe | 2 | 0 | 1 | 1 | 1:5 | -4 | 1 |
| 25 |
|
Defensa y Justicia | 2 | 0 | 0 | 2 | 2:4 | -2 | 0 |
| 26 |
|
Sarmiento de Junín | 2 | 0 | 0 | 2 | 0:5 | -5 | 0 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
