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| 03/09/2021 | 23:00 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 (0:0) | |
| 04/09/2021 | 01:15 | Huracán | - | Aldosivi | 2:0 (1:0) | |
| 17:30 | Atlético Tucumán | - | Arsenal de Sarandí | 0:0 (0:0) | ||
| 19:45 | Lanús | - | Sarmiento de Junín | 1:1 (0:0) | ||
| 19:45 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 (0:1) | ||
| 22:00 | Platense | - | San Lorenzo | 1:1 (0:0) | ||
| 05/09/2021 | 00:15 | Rosario Central | - | Boca Juniors | 1:2 (1:1) | |
| 17:30 | Patronato de Paraná | - | Talleres de Córdoba | 0:0 (0:0) | ||
| 17:30 | Godoy Cruz | - | Gimnasia de La Plata | 4:0 (0:0) | ||
| 23:00 | Racing Club | - | Banfield | 0:0 (0:0) | ||
| 06/09/2021 | 01:15 | River Plate | - | Independiente | 1:1 (0:1) | |
| 22:00 | Estudiantes | - | Argentinos Juniors | 1:1 (0:0) | ||
| 07/09/2021 | 00:15 | Vélez Sarsfield | - | Unión de Santa Fe | 4:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Talleres de Córdoba | 10 | 6 | 2 | 2 | 14:7 | 7 | 20 |
| 2 |
|
Lanús | 10 | 6 | 2 | 2 | 20:16 | 4 | 20 |
| 3 |
|
Independiente | 10 | 5 | 4 | 1 | 11:5 | 6 | 19 |
| 4 |
|
River Plate | 10 | 5 | 3 | 2 | 18:8 | 10 | 18 |
| 5 |
|
Racing Club | 10 | 4 | 5 | 1 | 8:1 | 7 | 17 |
| 6 |
|
Estudiantes | 10 | 5 | 2 | 3 | 16:10 | 6 | 17 |
| 7 |
|
Atlético Tucumán | 10 | 4 | 3 | 3 | 11:12 | -1 | 15 |
| 8 |
|
Colón de Santa Fe | 10 | 4 | 3 | 3 | 9:14 | -5 | 15 |
| 9 |
|
Boca Juniors | 10 | 3 | 5 | 2 | 8:7 | 1 | 14 |
| 10 |
|
Vélez Sarsfield | 10 | 3 | 4 | 3 | 13:6 | 7 | 13 |
| 11 |
|
Defensa y Justicia | 10 | 3 | 4 | 3 | 12:10 | 2 | 13 |
| 12 |
|
Argentinos Juniors | 10 | 3 | 4 | 3 | 8:7 | 1 | 13 |
| 13 |
|
Godoy Cruz | 10 | 4 | 1 | 5 | 14:15 | -1 | 13 |
| 14 |
|
Patronato de Paraná | 10 | 3 | 4 | 3 | 8:9 | -1 | 13 |
| 15 |
|
Aldosivi | 10 | 4 | 1 | 5 | 11:14 | -3 | 13 |
| 16 |
|
Huracán | 10 | 2 | 6 | 2 | 8:7 | 1 | 12 |
| 17 |
|
Newell's Old Boys | 10 | 3 | 3 | 4 | 11:13 | -2 | 12 |
| 18 |
|
San Lorenzo | 10 | 3 | 3 | 4 | 9:12 | -3 | 12 |
| 19 |
|
Unión de Santa Fe | 10 | 3 | 3 | 4 | 10:14 | -4 | 12 |
| 20 |
|
Sarmiento de Junín | 10 | 3 | 2 | 5 | 10:14 | -4 | 11 |
| 21 |
|
Rosario Central | 10 | 3 | 1 | 6 | 14:13 | 1 | 10 |
| 22 |
|
Platense | 10 | 2 | 4 | 4 | 13:15 | -2 | 10 |
| 23 |
|
Gimnasia de La Plata | 10 | 2 | 4 | 4 | 7:13 | -6 | 10 |
| 24 |
|
Banfield | 10 | 1 | 6 | 3 | 7:11 | -4 | 9 |
| 25 |
|
Central Córdoba SdE | 10 | 1 | 5 | 4 | 10:14 | -4 | 8 |
| 26 |
|
Arsenal de Sarandí | 10 | 1 | 4 | 5 | 5:18 | -13 | 7 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
