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| 30/04/2022 | 00:10 | Estudiantes de Río Cuarto | - | San Martín de San Juan | 3:1 (2:0) | |
| 18:10 | Villa Dálmine | - | Belgrano de Córdoba | 0:1 (0:0) | ||
| 19:30 | Almagro | - | Estudiantes de Caseros | 1:1 (1:0) | ||
| 19:30 | Deportivo Madryn | - | Chaco For Ever | 3:2 (0:1) | ||
| 19:30 | Deportivo Morón | - | San Telmo | 3:1 (2:0) | ||
| 19:30 | Flandria | - | All Boys | 0:1 (0:1) | ||
| 22:00 | Independiente Rivadavia | - | Chacarita Juniors | 2:3 (0:2) | ||
| 23:00 | Gimnasia de Jujuy | - | Güemes de SdE | 0:2 (0:0) | ||
| 23:30 | Alvarado | - | Atlanta | 3:1 (1:1) | ||
| 01/05/2022 | 01:15 | Almirante Brown | - | Deportivo Riestra | 1:1 (0:0) | |
| 02/05/2022 | 19:05 | Sacachispas | - | San Martín de Tucumán | 0:2 (0:1) | |
| 20:00 | Deportivo Maipú | - | Atlético Rafaela | 0:0 (0:0) | ||
| 20:30 | Mitre de SdE | - | Defensores de Belgrano | 0:0 (0:0) | ||
| 21:05 | Quilmes | - | Guillermo Brown | 1:0 (0:0) | ||
| 23:10 | Nueva Chicago | - | Ramón Santamarina | 4:0 (2:0) | ||
| 03/05/2022 | 01:10 | Temperley | - | Gimnasia de Mendoza | 1:1 (0:0) | |
| 04/05/2022 | 01:10 | Ferro Carril Oeste | - | Brown de Adrogué | 0:1 (0:0) | |
| 01/06/2022 | 18:00 | Instituto de Córdoba | - | Tristan Suárez | 3:0 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 12 | 10 | 1 | 1 | 18:8 | 10 | 31 |
| 2 |
|
San Martín de Tucumán | 13 | 8 | 3 | 2 | 20:12 | 8 | 27 |
| 3 |
|
Brown de Adrogué | 13 | 6 | 6 | 1 | 19:10 | 9 | 24 |
| 4 |
|
Instituto de Córdoba | 12 | 6 | 5 | 1 | 15:9 | 6 | 23 |
| 5 |
|
Chacarita Juniors | 13 | 6 | 4 | 3 | 24:18 | 6 | 22 |
| 6 |
|
All Boys | 12 | 5 | 6 | 1 | 17:11 | 6 | 21 |
| 7 |
|
Deportivo Maipú | 13 | 5 | 6 | 2 | 13:10 | 3 | 21 |
|
Estudiantes de Río Cuarto | 13 | 5 | 6 | 2 | 13:10 | 3 | 21 | |
| 9 |
|
Deportivo Madryn | 13 | 5 | 5 | 3 | 19:14 | 5 | 20 |
| 10 |
|
Gimnasia de Mendoza | 12 | 5 | 4 | 3 | 17:8 | 9 | 19 |
| 11 |
|
Deportivo Riestra | 12 | 4 | 7 | 1 | 10:6 | 4 | 19 |
| 12 |
|
Chaco For Ever | 13 | 3 | 9 | 1 | 14:11 | 3 | 18 |
| 13 |
|
Estudiantes de Caseros | 13 | 4 | 6 | 3 | 12:10 | 2 | 18 |
| 14 |
|
Almirante Brown | 13 | 4 | 6 | 3 | 16:15 | 1 | 18 |
| 15 |
|
Almagro | 13 | 5 | 3 | 5 | 12:15 | -3 | 18 |
| 16 |
|
Agropecuario Argentino | 12 | 4 | 5 | 3 | 13:9 | 4 | 17 |
| 17 |
|
San Martín de San Juan | 13 | 5 | 2 | 6 | 17:16 | 1 | 17 |
| 18 |
|
Guillermo Brown | 13 | 5 | 2 | 6 | 11:12 | -1 | 17 |
| 19 |
|
Defensores de Belgrano | 13 | 4 | 5 | 4 | 14:16 | -2 | 17 |
| 20 |
|
Nueva Chicago | 13 | 3 | 7 | 3 | 16:14 | 2 | 16 |
| 21 |
|
Quilmes | 12 | 3 | 7 | 2 | 15:13 | 2 | 16 |
| 22 |
|
Alvarado | 13 | 4 | 4 | 5 | 16:21 | -5 | 16 |
| 23 |
|
Deportivo Morón | 13 | 3 | 6 | 4 | 9:8 | 1 | 15 |
| 24 |
|
Atlanta | 13 | 3 | 6 | 4 | 14:15 | -1 | 15 |
| 25 |
|
Independiente Rivadavia | 12 | 4 | 3 | 5 | 14:16 | -2 | 15 |
| 26 |
|
Atlético Rafaela | 13 | 3 | 5 | 5 | 13:12 | 1 | 14 |
| 27 |
|
San Telmo | 12 | 2 | 6 | 4 | 12:20 | -8 | 12 |
| 28 |
|
Mitre de SdE | 12 | 2 | 5 | 5 | 11:13 | -2 | 11 |
| 29 |
|
Güemes de SdE | 12 | 2 | 5 | 5 | 8:12 | -4 | 11 |
| 30 |
|
Gimnasia de Jujuy | 13 | 2 | 5 | 6 | 9:20 | -11 | 11 |
| 31 |
|
Sacachispas | 12 | 1 | 7 | 4 | 10:13 | -3 | 10 |
| 32 |
|
Flandria | 13 | 2 | 4 | 7 | 17:22 | -5 | 10 |
| 33 |
|
Tristan Suárez | 13 | 1 | 7 | 5 | 15:21 | -6 | 10 |
| 34 |
|
Temperley | 13 | 2 | 4 | 7 | 11:18 | -7 | 10 |
| 35 |
|
Villa Dálmine | 13 | 1 | 7 | 5 | 12:21 | -9 | 10 |
| 36 |
|
Ferro Carril Oeste | 12 | 1 | 6 | 5 | 11:17 | -6 | 9 |
| 37 |
|
Ramón Santamarina | 13 | 1 | 5 | 7 | 10:21 | -11 | 8 |
| Promotion | |
| Playoffs | |
| Playoffs | |
| Relegation |
