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| 1st(1st leg) | Estudiantes de Caseros | - | Gimnasia de Mendoza | 1:0 (1:0) | ||
| 2nd (2nd leg) | Gimnasia de Mendoza | - | Estudiantes de Caseros | 0:1 (0:0) | ||
| 1st(1st leg): 30/10/2022 01:10 | 2nd (2nd leg): 05/11/2022 20:30 | Winner: Estudiantes de Caseros | ||||
| 1st(1st leg) | Defensores de Belgrano | - | Instituto de Córdoba | 0:0 (0:0) | ||
| 2nd (2nd leg) | Instituto de Córdoba | - | Defensores de Belgrano | 2:0 (1:0) | ||
| 1st(1st leg): 30/10/2022 21:05 | 2nd (2nd leg): 06/11/2022 00:10 | Winner: Instituto de Córdoba | ||||
