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| 1st(1st leg) | Deportivo Morón | - | Quilmes | 2:2 (1:1) | ||
| 2nd (2nd leg) | Quilmes | - | Deportivo Morón | 5:4 (1:1, 1:1) pso | ||
| 1st(1st leg): 21/11/2021 22:15 | 2nd (2nd leg): 27/11/2021 22:10 | Winner: Quilmes | ||||
| 1st(1st leg) | Independiente Rivadavia | - | Almirante Brown | 1:1 (0:0) | ||
| 2nd (2nd leg) | Almirante Brown | - | Independiente Rivadavia | 1:0 (1:0) | ||
| 1st(1st leg): 22/11/2021 20:00 | 2nd (2nd leg): 29/11/2021 20:00 | Winner: Almirante Brown | ||||
| 1st(1st leg) | San Martín de Tucumán | - | Ferro Carril Oeste | 1:3 (1:2) | ||
| 2nd (2nd leg) | Ferro Carril Oeste | - | San Martín de Tucumán | 0:1 (0:0) | ||
| 1st(1st leg): 22/11/2021 22:05 | 2nd (2nd leg): 30/11/2021 00:10 | Winner: Ferro Carril Oeste | ||||
