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| 1st(1st leg) | Colón de Santa Fe | - | Tigre | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tigre | - | Colón de Santa Fe | 3:2 (1:2) | ||
| 1st(1st leg): 12/04/2019 23:00 | 2nd (2nd leg): 21/04/2019 17:15 | Winner: Tigre | ||||
| 1st(1st leg) | Gimnasia de La Plata | - | Newell's Old Boys | 0:1 (0:0) | ||
| 2nd (2nd leg) | Newell's Old Boys | - | Gimnasia de La Plata | 1:3 (1:0) | ||
| 1st(1st leg): 13/04/2019 01:10 | 2nd (2nd leg): 21/04/2019 19:30 | Winner: Gimnasia de La Plata | ||||
| 1st(1st leg) | San Martín de San Juan | - | Talleres de Córdoba | 2:0 (0:0) | ||
| 2nd (2nd leg) | Talleres de Córdoba | - | San Martín de San Juan | 3:2 (1:0, 2:0) pso | ||
| 1st(1st leg): 13/04/2019 19:30 | 2nd (2nd leg): 20/04/2019 21:45 | Winner: Talleres de Córdoba | ||||
| 1st(1st leg) | Belgrano de Córdoba | - | Lanús | 3:2 (2:1) | ||
| 2nd (2nd leg) | Lanús | - | Belgrano de Córdoba | 2:0 (1:0) | ||
| 1st(1st leg): 13/04/2019 21:45 | 2nd (2nd leg): 20/04/2019 19:30 | Winner: Lanús | ||||
| 1st(1st leg) | San Martín de Tucumán | - | Unión de Santa Fe | 1:1 (0:1) | ||
| 2nd (2nd leg) | Unión de Santa Fe | - | San Martín de Tucumán | 3:0 (1:0) | ||
| 1st(1st leg): 14/04/2019 00:00 | 2nd (2nd leg): 21/04/2019 21:45 | Winner: Unión de Santa Fe | ||||
| 1st(1st leg) | Estudiantes | - | Banfield | 0:1 (0:1) | ||
| 2nd (2nd leg) | Banfield | - | Estudiantes | 0:2 (0:1) | ||
| 1st(1st leg): 14/04/2019 19:30 | 2nd (2nd leg): 19/04/2019 21:45 | Winner: Estudiantes | ||||
| 1st(1st leg) | San Lorenzo | - | Huracán | 0:0 (0:0) | ||
| 2nd (2nd leg) | Huracán | - | San Lorenzo | 3:4 (0:0, 0:0) pso | ||
| 1st(1st leg): 14/04/2019 21:45 | 2nd (2nd leg): 20/04/2019 00:00 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Argentinos Juniors | - | Independiente | 3:2 (1:1) | ||
| 2nd (2nd leg) | Independiente | - | Argentinos Juniors | 1:1 (0:0) | ||
| 1st(1st leg): 15/04/2019 00:00 | 2nd (2nd leg): 22/04/2019 00:00 | Winner: Argentinos Juniors | ||||
| 1st(1st leg) | Patronato de Paraná | - | Godoy Cruz | 1:1 (0:0) | ||
| 2nd (2nd leg) | Godoy Cruz | - | Patronato de Paraná | 5:4 (1:0, 1:1) pso | ||
| 1st(1st leg): 15/04/2019 23:00 | 2nd (2nd leg): 21/04/2019 00:00 | Winner: Godoy Cruz | ||||
| 1st(1st leg) | Rosario Central | - | Aldosivi | 0:2 (0:1) | ||
| 2nd (2nd leg) | Aldosivi | - | Rosario Central | 1:2 (0:1) | ||
| 1st(1st leg): 16/04/2019 01:10 | 2nd (2nd leg): 20/04/2019 17:15 | Winner: Aldosivi | ||||
