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| 1st(1st leg) | Buriram United | - | Bunyodkor PFK | 2:1 (1:1) | ||
| 2nd (2nd leg) | Bunyodkor PFK | - | Buriram United | 0:0 (0:0) | ||
| 1st(1st leg): 14/05/2013 12:00 | 2nd (2nd leg): 21/05/2013 15:00 | Winner: Buriram United | ||||
| 1st(1st leg) | Beijing Guoan | - | FC Seoul | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Seoul | - | Beijing Guoan | 3:1 (0:1) | ||
| 1st(1st leg): 14/05/2013 12:30 | 2nd (2nd leg): 21/05/2013 11:30 | Winner: FC Seoul | ||||
| 1st(1st leg) | Al Gharafa | - | Al Shabab | 1:2 (1:0) | ||
| 2nd (2nd leg) | Al Shabab | - | Al Gharafa | 3:0 (1:0) | ||
| 1st(1st leg): 14/05/2013 16:45 | 2nd (2nd leg): 21/05/2013 18:50 | Winner: Al Shabab | ||||
| 1st(1st leg) | El Jaish SC | - | Al Ahli SFC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Al Ahli SFC | - | El Jaish SC | 2:0 (2:0) | ||
| 1st(1st leg): 14/05/2013 17:00 | 2nd (2nd leg): 21/05/2013 18:45 | Winner: Al Ahli SFC | ||||
| 1st(1st leg) | Central Coast Mariners | - | Guangzhou Evergrande | 1:2 (1:1) | ||
| 2nd (2nd leg) | Guangzhou Evergrande | - | Central Coast Mariners | 3:0 (2:0) | ||
| 1st(1st leg): 15/05/2013 10:30 | 2nd (2nd leg): 22/05/2013 13:00 | Winner: Guangzhou Evergrande | ||||
| 1st(1st leg) | Jeonbuk FC | - | Kashiwa Reysol | 0:2 (0:1) | ||
| 2nd (2nd leg) | Kashiwa Reysol | - | Jeonbuk FC | 3:2 (1:1) | ||
| 1st(1st leg): 15/05/2013 11:00 | 2nd (2nd leg): 22/05/2013 11:00 | Winner: Kashiwa Reysol | ||||
| 1st(1st leg) | Al Shabab Al Arabi | - | Esteghlal | 2:4 (1:0) | ||
| 2nd (2nd leg) | Esteghlal | - | Al Shabab Al Arabi | 0:0 (0:0) | ||
| 1st(1st leg): 15/05/2013 16:40 | 2nd (2nd leg): 22/05/2013 17:30 | Winner: Esteghlal | ||||
| 1st(1st leg) | Al Hilal | - | Lekhwiya SC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Lekhwiya SC | - | Al Hilal | 2:2 (1:0) | ||
| 1st(1st leg): 15/05/2013 19:00 | 2nd (2nd leg): 22/05/2013 16:30 | Winner: Lekhwiya SC | ||||
