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| 04/12/2021 | 10:00 | 1. FC Saarbrücken | - | 1. FC Nürnberg | 0:1 (0:1) | |
| 10:00 | Bayern München | - | 1. FSV Mainz 05 | 7:2 (2:0) | ||
| 12:00 | SC Freiburg | - | FC-Astoria Walldorf | 1:1 (1:1) | ||
| 12:00 | SV Darmstadt 98 | - | 1. FC Kaiserslautern | 1:3 (1:1) | ||
| 13:00 | 1. FC Heidenheim 1846 | - | SpVgg Unterhaching | 4:0 (3:0) | ||
| 13:30 | VfB Stuttgart | - | Hessen Kassel | 7:0 (2:0) | ||
| 05/12/2021 | 12:00 | SSV Ulm 1846 | - | Karlsruher SC | 0:5 (0:2) | |
| 13:30 | FC Augsburg | - | SpVgg Greuther Fürth | 5:2 (4:0) | ||
| 01/03/2022 | 10:00 | Kickers Offenbach | - | FC Ingolstadt 04 | 1:1 (1:1) | |
| 12/03/2022 | 12:00 | Eintracht Frankfurt | - | 1899 Hoffenheim | 1:0 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 12 | 10 | 1 | 1 | 29:13 | 16 | 31 |
| 2 |
|
VfB Stuttgart | 11 | 8 | 2 | 1 | 34:9 | 25 | 26 |
| 3 |
|
FC Augsburg | 11 | 7 | 3 | 1 | 32:16 | 16 | 24 |
| 4 |
|
1. FSV Mainz 05 | 12 | 7 | 1 | 4 | 36:22 | 14 | 22 |
| 5 |
|
1899 Hoffenheim | 12 | 6 | 3 | 3 | 40:24 | 16 | 21 |
| 6 |
|
Eintracht Frankfurt | 11 | 6 | 2 | 3 | 28:15 | 13 | 20 |
| 7 |
|
SpVgg Unterhaching | 11 | 6 | 2 | 3 | 18:17 | 1 | 20 |
| 8 |
|
Bayern München | 11 | 6 | 1 | 4 | 37:17 | 20 | 19 |
| 9 |
|
1. FC Heidenheim 1846 | 12 | 5 | 2 | 5 | 23:19 | 4 | 17 |
| 10 |
|
SV Darmstadt 98 | 12 | 4 | 4 | 4 | 14:20 | -6 | 16 |
| 11 |
|
Karlsruher SC | 11 | 3 | 6 | 2 | 19:16 | 3 | 15 |
| 12 |
|
FC Ingolstadt 04 | 11 | 4 | 3 | 4 | 20:18 | 2 | 15 |
| 13 |
|
SC Freiburg | 12 | 4 | 3 | 5 | 22:26 | -4 | 15 |
| 14 |
|
1. FC Kaiserslautern | 11 | 5 | 0 | 6 | 25:34 | -9 | 15 |
| 15 |
|
FC-Astoria Walldorf | 11 | 3 | 5 | 3 | 20:19 | 1 | 14 |
| 16 |
|
SpVgg Greuther Fürth | 12 | 3 | 3 | 6 | 16:27 | -11 | 12 |
| 17 |
|
Kickers Offenbach | 12 | 3 | 1 | 8 | 16:33 | -17 | 10 |
| 18 |
|
SSV Ulm 1846 | 11 | 3 | 0 | 8 | 15:26 | -11 | 9 |
| 19 |
|
Stuttgarter Kickers | 11 | 2 | 2 | 7 | 16:32 | -16 | 8 |
| 20 |
|
1. FC Saarbrücken | 11 | 2 | 0 | 9 | 8:23 | -15 | 6 |
| 21 |
|
Hessen Kassel | 12 | 1 | 0 | 11 | 5:47 | -42 | 3 |
| Playoffs | |
| Relegation |
