| 1. Round | 16/02/2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 2. Round | 22/02/2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 3. Round | 03/03/2022 | Barnechea | - | San Luis | 3:1 | ||||
| 4. Round | 09/03/2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 6. Round | 23/03/2022 | Rangers | - | San Luis | 2:3 | ||||
| 10. Round | 21/04/2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 18. Round | 04/07/2022 | San Luis | - | Cobreloa | 0:0 |  |
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| 22. Round | 01/08/2022 | Santiago Morning | - | San Luis | 1:0 | ||||
| 24. Round | 16/08/2022 | Copiapó | - | San Luis | 1:1 |  |
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| 25. Round | 24/08/2022 | San Luis | - | Unión San Felipe | 2:2 | ||||
| 26. Round | 31/08/2022 | Melipilla | - | San Luis | 1:2 | |
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| 27. Round | 07/09/2022 | San Luis | - | Puerto Montt | 0:3 | ||||
| 29. Round | 27/09/2022 | Deportes Temuco | - | San Luis | 1:0 | ||||
| 30. Round | 04/10/2022 | San Luis | - | Deportes Iquique | 0:0 | ||||
| 31. Round | 10/10/2022 | Fernández Vial | - | San Luis | 1:1 | |
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| 32. Round | 16/10/2022 | San Luis | - | Santa Cruz | 0:0 | ||||
| 33. Round | 24/10/2022 | San Luis | - | Recoleta | 2:1 | ||||
| 34. Round | 01/11/2022 | Universidad de Concepción | - | San Luis | 3:1 |
Chile