| 1. Round | 23/08/1980 | AC Bellinzona | - | Servette FC | 0:0 | ||||
| 2. Round | 30/08/1980 | Servette FC | - | FC Nordstern Basel | 1:0 | ||||
| 4. Round | 13/09/1980 | Servette FC | - | BSC Young Boys | 1:4 | ||||
| 5. Round | 20/09/1980 | CS Chênois | - | Servette FC | 2:2 | ||||
| 6. Round | 04/10/1980 | Servette FC | - | FC Zürich | 1:2 |  |
|||
| 7. Round | 08/10/1980 | Servette FC | - | FC Luzern | 2:2 | ||||
| 9. Round | 18/10/1980 | Servette FC | - | FC Chiasso | 4:2 | ||||
| 14. Round | 01/03/1981 | Servette FC | - | AC Bellinzona | 0:1 | ||||
| 16. Round | 15/03/1981 | Servette FC | - | Lausanne Sports | 0:0 | ||||
| 17. Round | 21/03/1981 | BSC Young Boys | - | Servette FC | 3:2 | ||||
| 13. Round | 01/04/1981 | Grasshopper Club Zürich | - | Servette FC | 2:1 | ||||
| 18. Round | 05/04/1981 | Servette FC | - | CS Chênois | 3:1 | ||||
| 19. Round | 12/04/1981 | FC Zürich | - | Servette FC | 3:2 | ||||
| 22. Round | 09/05/1981 | Servette FC | - | FC Basel 1893 | 2:1 |  |
|||
| 23. Round | 16/05/1981 | FC Sion | - | Servette FC | 0:3 |
Egypt