| 1. Round | 21/02/2021 | Alianza | - | Sporting San Miguelito | 0:0 | ||||
| 2. Round | 28/02/2021 | Sporting San Miguelito | - | Plaza Amador | 0:0 | ||||
| 3. Round | 07/03/2021 | Tauro FC | - | Sporting San Miguelito | 0:1 | ||||
| 5. Round | 18/03/2021 | Sporting San Miguelito | - | Árabe Unido | 3:2 | ||||
| 6. Round | 21/03/2021 | UD Universitario | - | Sporting San Miguelito | 2:1 | ||||
| 7. Round | 24/03/2021 | Sporting San Miguelito | - | Independiente de La Chorrera | 1:3 | ||||
| 8. Round | 29/03/2021 | Sporting San Miguelito | - | Veraguas Club Deportivo | 1:1 |  |
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| 9. Round | 05/04/2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | ||||
| 10. Round | 10/04/2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | ||||
| 12. Round | 21/04/2021 | Sporting San Miguelito | - | Alianza | 0:0 | ||||
| 13. Round | 25/04/2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | ||||
| 14. Round | 28/04/2021 | Sporting San Miguelito | - | Tauro FC | 2:2 | |
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| 15. Round | 06/05/2021 | Sporting San Miguelito | - | Deportivo del Este | 1:0 | |
Panama