| 1. Round | 08/08/2021 | Würzburger Kickers | - | SC Freiburg | 0:1 | ||||
| 2. Round | 26/10/2021 | VfL Osnabrück | - | SC Freiburg | 2:3 pso |  |
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| Round of 16 | 19/01/2022 | 1899 Hoffenheim | - | SC Freiburg | 1:4 | |
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| Quarter-finals | 02/03/2022 | VfL Bochum | - | SC Freiburg | 1:2 aet | ||||
| Semi-finals | 19/04/2022 | Hamburger SV | - | SC Freiburg | 1:3 | |
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| Final | 21/05/2022 | SC Freiburg | - | RB Leipzig | 2:4 pso |
Germany
