| 3. Round | 22/08/2021 | Veraguas Club Deportivo | - | Herrera FC | 1:1 | ||||
| 4. Round | 29/08/2021 | Atlético Chiriquí | - | Veraguas Club Deportivo | 2:0 | ||||
| 5. Round | 05/09/2021 | Veraguas Club Deportivo | - | San Francisco FC | 1:0 | ||||
| 6. Round | 12/09/2021 | Veraguas Club Deportivo | - | Plaza Amador | 1:1 | ||||
| 10. Round | 09/10/2021 | Alianza | - | Veraguas Club Deportivo | 0:1 |  |
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| 11. Round | 16/10/2021 | Tauro FC | - | Veraguas Club Deportivo | 2:0 | ||||
| 12. Round | 24/10/2021 | Veraguas Club Deportivo | - | UD Universitario | 1:0 | ||||
| 13. Round | 31/10/2021 | Independiente de La Chorrera | - | Veraguas Club Deportivo | 3:1 | |
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| 14. Round | 06/11/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:1 | |
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| 15. Round | 13/11/2021 | Veraguas Club Deportivo | - | Atlético Chiriquí | 0:2 | ||||
| 16. Round | 20/11/2021 | San Francisco FC | - | Veraguas Club Deportivo | 0:1 | |
Panama