| 1. Round | 17/08/2024 | Newcastle United | - | Southampton FC | 1:0 | ||||
| 2. Round | 24/08/2024 | Southampton FC | - | Nottingham Forest | 0:1 | ||||
| 3. Round | 31/08/2024 | Brentford FC | - | Southampton FC | 3:1 | ||||
| 4. Round | 14/09/2024 | Southampton FC | - | Manchester United | 0:3 | ||||
| 5. Round | 21/09/2024 | Southampton FC | - | Ipswich Town | 1:1 |  |
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| 6. Round | 30/09/2024 | AFC Bournemouth | - | Southampton FC | 3:1 |  |
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| 7. Round | 05/10/2024 | Arsenal FC | - | Southampton FC | 3:1 | |
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| 8. Round | 19/10/2024 | Southampton FC | - | Leicester City | 2:3 | |
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| 9. Round | 26/10/2024 | Manchester City | - | Southampton FC | 1:0 | ||||
| 10. Round | 02/11/2024 | Southampton FC | - | Everton FC | 1:0 | |
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| 11. Round | 09/11/2024 | Wolverhampton Wanderers | - | Southampton FC | 2:0 | ||||
| 12. Round | 24/11/2024 | Southampton FC | - | Liverpool FC | 2:3 | ||||
| 13. Round | 29/11/2024 | Brighton & Hove Albion | - | Southampton FC | 1:1 | |
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| 15. Round | 07/12/2024 | Aston Villa | - | Southampton FC | 1:0 | ||||
| 16. Round | 15/12/2024 | Southampton FC | - | Tottenham Hotspur | 0:5 | ||||
| 17. Round | 22/12/2024 | Fulham FC | - | Southampton FC | 0:0 |
England