| 1. Round | 21/08/2010 | 1899 Hoffenheim | - | Werder Bremen | 4:1 | ||||
| 2. Round | 28/08/2010 | FC St. Pauli | - | 1899 Hoffenheim | 0:1 | ||||
| 3. Round | 10/09/2010 | 1899 Hoffenheim | - | FC Schalke 04 | 2:0 | ||||
| 4. Round | 18/09/2010 | 1. FC Kaiserslautern | - | 1899 Hoffenheim | 2:2 | ||||
| 5. Round | 21/09/2010 | 1899 Hoffenheim | - | Bayern München | 1:2 |  |
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| 6. Round | 24/09/2010 | 1. FC Köln | - | 1899 Hoffenheim | 1:1 | ||||
| 7. Round | 02/10/2010 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 4:2 | |
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| 9. Round | 24/10/2010 | Borussia Dortmund | - | 1899 Hoffenheim | 1:1 | ||||
| 10. Round | 31/10/2010 | 1899 Hoffenheim | - | Hannover 96 | 4:0 | ||||
| 11. Round | 06/11/2010 | Hamburger SV | - | 1899 Hoffenheim | 2:1 | ||||
| 13. Round | 20/11/2010 | Eintracht Frankfurt | - | 1899 Hoffenheim | 0:4 | ||||
| 15. Round | 04/12/2010 | VfB Stuttgart | - | 1899 Hoffenheim | 1:1 | |
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| 18. Round | 15/01/2011 | Werder Bremen | - | 1899 Hoffenheim | 2:1 | ||||
| 19. Round | 23/01/2011 | 1899 Hoffenheim | - | FC St. Pauli | 2:2 | ||||
| 20. Round | 29/01/2011 | FC Schalke 04 | - | 1899 Hoffenheim | 0:1 | ||||
| 22. Round | 12/02/2011 | Bayern München | - | 1899 Hoffenheim | 4:0 | |
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| 30. Round | 16/04/2011 | 1899 Hoffenheim | - | Eintracht Frankfurt | 1:0 |
Germany