| 2. Round | 19/08/2007 | Bor. Mönchengladbach | - | 1899 Hoffenheim | 0:0 |  |
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| 3. Round | 26/08/2007 | 1899 Hoffenheim | - | TSV 1860 München | 0:3 | ||||
| 4. Round | 03/09/2007 | SC Freiburg | - | 1899 Hoffenheim | 3:2 | |
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| 6. Round | 21/09/2007 | SC Paderborn 07 | - | 1899 Hoffenheim | 0:2 | ||||
| 7. Round | 25/09/2007 | Erzgebirge Aue | - | 1899 Hoffenheim | 2:2 | |
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| 8. Round | 30/09/2007 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 1:0 | ||||
| 18. Round | 01/02/2008 | SV Wehen Wiesbaden | - | 1899 Hoffenheim | 0:2 | ||||
| 19. Round | 10/02/2008 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 4:2 | ||||
| 26. Round | 28/03/2008 | 1899 Hoffenheim | - | FC Augsburg | 2:0 | ||||
| 29. Round | 16/04/2008 | FC St. Pauli | - | 1899 Hoffenheim | 3:1 | |
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| 30. Round | 27/04/2008 | 1899 Hoffenheim | - | FC Carl Zeiss Jena | 5:0 | ||||
| 31. Round | 04/05/2008 | 1. FC Köln | - | 1899 Hoffenheim | 3:1 | ||||
| 32. Round | 07/05/2008 | 1899 Hoffenheim | - | TuS Koblenz | 3:1 |  |
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| 33. Round | 11/05/2008 | Kickers Offenbach | - | 1899 Hoffenheim | 1:1 | ||||
| 34. Round | 18/05/2008 | 1899 Hoffenheim | - | SpVgg Greuther Fürth | 5:0 |
Germany