| 1. Round | 14/08/2021 | 1899 Hoffenheim [Youth] | - | 1. FC Kaiserslautern [Youth] | 6:2 | ||||
| 2. Round | 21/08/2021 | Stuttgarter Kickers [Youth] | - | 1899 Hoffenheim [Youth] | 3:5 | ||||
| 3. Round | 11/09/2021 | 1899 Hoffenheim [Youth] | - | SV Darmstadt 98 [Youth] | 7:1 | ||||
| 4. Round | 18/09/2021 | 1. FC Heidenheim 1846 [Youth] | - | 1899 Hoffenheim [Youth] | 3:0 | ||||
| 5. Round | 25/09/2021 | 1899 Hoffenheim [Youth] | - | Kickers Offenbach [Youth] | 6:1 |  |
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| 8. Round | 24/10/2021 | Bayern München [Youth] | - | 1899 Hoffenheim [Youth] | 1:1 | ||||
| 14. Round | 12/02/2022 | 1899 Hoffenheim [Youth] | - | Hessen Kassel [Youth] | 5:0 | ||||
| 15. Round | 19/02/2022 | 1. FC Nürnberg [Youth] | - | 1899 Hoffenheim [Youth] | 1:4 |  |
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| 17. Round | 05/03/2022 | 1. FSV Mainz 05 [Youth] | - | 1899 Hoffenheim [Youth] | 3:2 | |
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Germany