| Round of 32 | 18/02/2016 | Shakhtar Donetsk | - | FC Schalke 04 | 0:0 | ||||
| Round of 32 | 25/02/2016 | FC Schalke 04 | - | Shakhtar Donetsk | 0:3 |  |
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| Round of 16 | 17/03/2016 | RSC Anderlecht | - | Shakhtar Donetsk | 0:1 | |
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| Quarter-finals | 07/04/2016 | Sporting Braga | - | Shakhtar Donetsk | 1:2 | ||||
| Quarter-finals | 14/04/2016 | Shakhtar Donetsk | - | Sporting Braga | 4:0 | ||||
| Semi-finals | 28/04/2016 | Shakhtar Donetsk | - | Sevilla FC | 2:2 |  |
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| Semi-finals | 05/05/2016 | Sevilla FC | - | Shakhtar Donetsk | 3:1 | |
Ukraine