| 1. Round | 13/03/2022 | Rio Grande Valley FC | - | Oakland Roots | 1:0 | ||||
| 1. Round | 24/03/2022 | Los Angeles Galaxy II | - | Rio Grande Valley FC | 1:0 | ||||
| 2. Round | 16/04/2022 | New York RB II | - | Rio Grande Valley FC | 0:1 | ||||
| 2. Round | 24/04/2022 | Rio Grande Valley FC | - | Sacramento Republic | 2:1 |  |
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| 3. Round | 01/05/2022 | Rio Grande Valley FC | - | Orange County SC | 1:2 | ||||
| 4. Round | 02/06/2022 | Atlanta United II | - | Rio Grande Valley FC | 3:4 | ||||
| 4. Round | 05/06/2022 | Rio Grande Valley FC | - | Los Angeles Galaxy II | 0:1 | ||||
| 4. Round | 30/06/2022 | Rio Grande Valley FC | - | El Paso Locomotive | 0:0 | ||||
| 5. Round | 07/07/2022 | New Mexico United | - | Rio Grande Valley FC | 1:0 |
USA