| 1. Round | 23/08/2021 | Sampdoria | - | AC Milan | 0:1 |  |
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| 2. Round | 29/08/2021 | AC Milan | - | Cagliari Calcio | 4:1 | ||||
| 4. Round | 19/09/2021 | Juventus | - | AC Milan | 1:1 | ||||
| 7. Round | 03/10/2021 | Atalanta | - | AC Milan | 2:3 | ||||
| 9. Round | 23/10/2021 | Bologna FC | - | AC Milan | 2:4 | ||||
| 10. Round | 26/10/2021 | AC Milan | - | Torino FC | 1:0 | ||||
| 11. Round | 31/10/2021 | AS Roma | - | AC Milan | 1:2 | ||||
| 12. Round | 07/11/2021 | AC Milan | - | Inter | 1:1 | ||||
| 13. Round | 20/11/2021 | ACF Fiorentina | - | AC Milan | 4:3 | ||||
| 14. Round | 28/11/2021 | AC Milan | - | Sassuolo Calcio | 1:3 | |
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| 15. Round | 01/12/2021 | Genoa CFC | - | AC Milan | 0:3 |
Denmark
