| 5. Round | 11/09/2010 | SC Verl | - | FC Schalke 04 II | 4:1 |  |
|||
| 15. Round | 20/11/2010 | FC Schalke 04 II | - | VfL Bochum II | 2:1 | ||||
| 17. Round | 05/12/2010 | FC Schalke 04 II | - | Bayer Leverkusen II | 1:1 | ||||
| 20. Round | 12/02/2011 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 1:0 | ||||
| 21. Round | 20/02/2011 | 1. FC Köln II | - | FC Schalke 04 II | 1:1 |  |
Spain