| 1. Round | 07/01/2022 | Puebla FC [U20] | - | CF América [U20] | 1:5 | ||||
| 3. Round | 27/01/2022 | CF América [U20] | - | Atlas Guadalajara [U20] | 3:1 |  |
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| 5. Round | 12/02/2022 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 2. Round | 16/02/2022 | Mazatlán FC [U20] | - | CF América [U20] | 2:1 | ||||
| 6. Round | 20/02/2022 | CF América [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 8. Round | 01/03/2022 | CF América [U20] | - | Gallos Blancos [U20] | 2:0 | ||||
| 9. Round | 05/03/2022 | CF Monterrey [U20] | - | CF América [U20] | 3:2 | ||||
| 10. Round | 12/03/2022 | Deportivo Guadalajara [U20] | - | CF América [U20] | 0:2 | ||||
| 11. Round | 20/03/2022 | CF América [U20] | - | Deportivo Toluca [U20] | 2:0 | |
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| 12. Round | 02/04/2022 | Club Necaxa [U20] | - | CF América [U20] | 1:2 |  |
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| 13. Round | 09/04/2022 | CF América [U20] | - | FC Juárez [U20] | 6:0 | |
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| 14. Round | 15/04/2022 | Club Tijuana [U20] | - | CF América [U20] | 4:0 | ||||
| 15. Round | 20/04/2022 | CF América [U20] | - | Club León [U20] | 2:1 |  |
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| 17. Round | 30/04/2022 | CF América [U20] | - | Cruz Azul [U20] | 2:0 | |
Mexico