| Group G | 17/09/2015 | Dnipro Dnipropetrovsk | - | Lazio Roma | 1:1 |  |
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| Group G | 01/10/2015 | Lazio Roma | - | AS Saint-Étienne | 3:2 | ||||
| Group G | 22/10/2015 | Lazio Roma | - | Rosenborg BK | 3:1 | |
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| Group G | 26/11/2015 | Lazio Roma | - | Dnipro Dnipropetrovsk | 3:1 | |
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| Round of 32 | 18/02/2016 | Galatasaray | - | Lazio Roma | 1:1 | |
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| Round of 32 | 25/02/2016 | Lazio Roma | - | Galatasaray | 3:1 | ||||
| Round of 16 | 10/03/2016 | AC Sparta Praha | - | Lazio Roma | 1:1 |
Spain
