| 1. Round | 22/07/2017 | Hallescher FC | - | SC Paderborn 07 | 4:4 | ||||
| 2. Round | 29/07/2017 | SC Paderborn 07 | - | Chemnitzer FC | 3:2 | ||||
| 4. Round | 05/08/2017 | SC Paderborn 07 | - | SG Sonnenhof Großaspach | 5:0 | ||||
| 6. Round | 25/08/2017 | SC Paderborn 07 | - | SV Meppen | 1:0 | ||||
| 7. Round | 09/09/2017 | Würzburger Kickers | - | SC Paderborn 07 | 2:3 | ||||
| 8. Round | 16/09/2017 | SC Paderborn 07 | - | Preußen Münster | 2:1 | ||||
| 11. Round | 01/10/2017 | FSV Zwickau | - | SC Paderborn 07 | 1:3 | ||||
| 12. Round | 14/10/2017 | SC Paderborn 07 | - | Werder Bremen II | 7:1 | ||||
| 13. Round | 21/10/2017 | SC Paderborn 07 | - | VfR Aalen | 3:0 | ||||
| 16. Round | 18/11/2017 | SpVgg Unterhaching | - | SC Paderborn 07 | 0:3 | ||||
| 17. Round | 24/11/2017 | SC Paderborn 07 | - | Karlsruher SC | 0:2 | ||||
| 30. Round | 17/03/2018 | SC Paderborn 07 | - | FSV Zwickau | 2:0 | ||||
| 31. Round | 23/03/2018 | Werder Bremen II | - | SC Paderborn 07 | 0:2 | ||||
| 25. Round | 27/03/2018 | SV Meppen | - | SC Paderborn 07 | 0:0 |  |
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| 36. Round | 28/04/2018 | Karlsruher SC | - | SC Paderborn 07 | 0:0 | ||||
| 38. Round | 12/05/2018 | Fortuna Köln | - | SC Paderborn 07 | 2:4 |
Austria