| 2. Round | 12/02/2022 | Alianza Atlético | - | Universidad Técnica | 1:0 | ||||
| 3. Round | 20/02/2022 | Academia Cantolao | - | Alianza Atlético | 1:3 |  |
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| 4. Round | 27/02/2022 | Alianza Atlético | - | Alianza Lima | 4:2 | |
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| 5. Round | 06/03/2022 | Carlos Stein | - | Alianza Atlético | 0:1 | ||||
| 7. Round | 20/03/2022 | Universidad Cesar Vallejo | - | Alianza Atlético | 3:1 | |
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| 8. Round | 02/04/2022 | Alianza Atlético | - | Deportivo Municipal | 2:2 | ||||
| 9. Round | 10/04/2022 | Cienciano | - | Alianza Atlético | 5:0 | |
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| 10. Round | 15/04/2022 | Alianza Atlético | - | Deportivo Binacional | 2:0 | ||||
| 11. Round | 24/04/2022 | AD Tarma | - | Alianza Atlético | 1:2 | ||||
| 12. Round | 01/05/2022 | Alianza Atlético | - | Ayacucho FC | 2:1 | ||||
| 13. Round | 07/05/2022 | Universitario de Deportes | - | Alianza Atlético | 3:1 | |
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| 15. Round | 22/05/2022 | Atlético Grau | - | Alianza Atlético | 1:2 | ||||
| 16. Round | 30/05/2022 | Sport Huancayo | - | Alianza Atlético | 4:1 | |
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| 17. Round | 19/06/2022 | Alianza Atlético | - | Mannucci | 0:0 | |
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| 18. Round | 25/06/2022 | Sporting Cristal | - | Alianza Atlético | 1:0 | |
Uruguay