| 6. Round | 13/02/2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Round | 19/02/2021 | Atlético San Luis | - | Santos Laguna | 1:0 |  |
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| 8. Round | 26/02/2021 | Atlético San Luis | - | UANL Tigres | 2:2 | |
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| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Round | 06/03/2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Round | 15/03/2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 24/04/2021 | Cruz Azul | - | Atlético San Luis | 3:2 | |
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| 17. Round | 30/04/2021 | Atlético San Luis | - | CF Pachuca | 1:5 | |
Argentina
Mexico