| Round of 16 | 23/02/2018 | Cibao FC | - | Deportivo Guadalajara | 0:2 | ||||
| Round of 16 | 01/03/2018 | Deportivo Guadalajara | - | Cibao FC | 5:0 | ||||
| Quarter-finals | 08/03/2018 | Seattle Sounders | - | Deportivo Guadalajara | 1:0 | ||||
| Quarter-finals | 15/03/2018 | Deportivo Guadalajara | - | Seattle Sounders | 3:0 | ||||
| Semi-finals | 05/04/2018 | Deportivo Guadalajara | - | New York RB | 1:0 |  |
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| Semi-finals | 11/04/2018 | New York RB | - | Deportivo Guadalajara | 0:0 | ||||
| Final | 18/04/2018 | Toronto FC | - | Deportivo Guadalajara | 1:2 |  |
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| Final | 26/04/2018 | Deportivo Guadalajara | - | Toronto FC | 4:2 pso |
Mexico