| 1. Round | 19/09/2021 | Mazatlán FC [] | - | Club León [] | 2:2 | ||||
| 2. Round | 25/09/2021 | Club León [] | - | UANL Tigres [] | 2:1 |  |
|||
| 4. Round | 09/10/2021 | Deportivo Guadalajara [] | - | Club León [] | 3:0 | ||||
| 5. Round | 16/10/2021 | Club León [] | - | Mazatlán FC [] | 4:2 | ||||
| 6. Round | 23/10/2021 | Atlas Guadalajara [] | - | Club León [] | 2:0 | ||||
| 7. Round | 30/10/2021 | Club León [] | - | Atlético San Luis [] | 2:0 | |
|||
| 8. Round | 06/11/2021 | Club Necaxa [] | - | Club León [] | 3:3 | ||||
| 9. Round | 13/11/2021 | CF Monterrey [] | - | Club León [] | 2:2 | |
|||
| 10. Round | 20/11/2021 | Club León [] | - | Santos Laguna [] | 4:2 | |
Mexico