| 1. Round | 29/07/2021 | CF Monterrey II | - | Cancún FC | 1:2 | ||||
| 3. Round | 11/08/2021 | Cancún FC | - | Correcaminos UAT | 0:1 | ||||
| 4. Round | 20/08/2021 | Atlante | - | Cancún FC | 1:0 |  |
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| 5. Round | 26/08/2021 | Cancún FC | - | Mineros de Zacatecas | 3:1 | |
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| 6. Round | 03/09/2021 | Dorados de Sinaloa | - | Cancún FC | 2:0 | ||||
| 7. Round | 08/09/2021 | Cancún FC | - | Venados FC | 0:1 | ||||
| 8. Round | 16/09/2021 | Tepatitlán | - | Cancún FC | 1:2 | ||||
| 9. Round | 22/09/2021 | Cancún FC | - | Leones Negros | 0:1 | ||||
| 10. Round | 30/09/2021 | Cancún FC | - | TM Fútbol Club | 1:1 | ||||
| 11. Round | 07/10/2021 | Tapatío | - | Cancún FC | 1:1 | ||||
| 12. Round | 14/10/2021 | Cancún FC | - | Atlético Morelia | 0:1 | |
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| 13. Round | 20/10/2021 | Pumas Tabasco | - | Cancún FC | 0:0 | |
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| 14. Round | 27/10/2021 | Cancún FC | - | Cimarrones de Sonora | 2:2 | |
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| 16. Round | 10/11/2021 | Cancún FC | - | Alebrijes de Oaxaca | 1:2 | |
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| 17. Round | 17/11/2021 | Club Celaya | - | Cancún FC | 3:1 |
Mexico