| 1. Round | 09/01/2022 | Deportivo Guadalajara [U18] | - | Mazatlán FC [U18] | 4:1 | ||||
| 3. Round | 21/01/2022 | Mazatlán FC [U18] | - | Deportivo Toluca [U18] | 0:0 | ||||
| 4. Round | 06/02/2022 | UANL Tigres [U18] | - | Mazatlán FC [U18] | 3:3 | ||||
| 5. Round | 11/02/2022 | Mazatlán FC [U18] | - | Club Tijuana [U18] | 0:2 |  |
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| 2. Round | 16/02/2022 | Mazatlán FC [U18] | - | CF América [U18] | 0:3 | |
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| 6. Round | 20/02/2022 | Gallos Blancos [U18] | - | Mazatlán FC [U18] | 0:1 | ||||
| 7. Round | 24/02/2022 | CF Pachuca [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U18] | - | Club Necaxa [U18] | 2:0 | ||||
| 10. Round | 11/03/2022 | CF Monterrey [U18] | - | Mazatlán FC [U18] | 2:2 | ||||
| 11. Round | 18/03/2022 | Mazatlán FC [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 12. Round | 01/04/2022 | Atlético San Luis [U18] | - | Mazatlán FC [U18] | 3:1 | |
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| 13. Round | 08/04/2022 | Mazatlán FC [U18] | - | Cruz Azul [U18] | 1:2 | |
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| 14. Round | 14/04/2022 | Atlas Guadalajara [U18] | - | Mazatlán FC [U18] | 4:1 | ||||
| 16. Round | 22/04/2022 | FC Juárez [U18] | - | Mazatlán FC [U18] | 2:2 |
Mexico