| Group E | 21/10/2021 | Maccabi Haifa | - | Slavia Praha | 1:0 | ||||
| Group E | 04/11/2021 | Slavia Praha | - | Maccabi Haifa | 1:0 | ||||
| Group E | 25/11/2021 | Slavia Praha | - | Feyenoord | 2:2 |  |
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| Group E | 09/12/2021 | 1. FC Union Berlin | - | Slavia Praha | 1:1 | ||||
| Play-offs | 17/02/2022 | Fenerbahçe | - | Slavia Praha | 2:3 | ||||
| Play-offs | 24/02/2022 | Slavia Praha | - | Fenerbahçe | 3:2 | ||||
| Round of 16 | 10/03/2022 | Slavia Praha | - | LASK | 4:1 | |
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| Round of 16 | 17/03/2022 | LASK | - | Slavia Praha | 4:3 | |
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| Quarter-finals | 07/04/2022 | Feyenoord | - | Slavia Praha | 3:3 | |
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| Quarter-finals | 14/04/2022 | Slavia Praha | - | Feyenoord | 1:3 |
Nigeria