| Group A | 22/10/2020 | BSC Young Boys | - | AS Roma | 1:2 | ||||
| Group A | 29/10/2020 | AS Roma | - | CSKA Sofia | 0:0 | ||||
| Group A | 05/11/2020 | AS Roma | - | CFR Cluj | 5:0 |  |
|||
| Group A | 03/12/2020 | AS Roma | - | BSC Young Boys | 3:1 | ||||
| Group A | 10/12/2020 | CSKA Sofia | - | AS Roma | 3:1 | ||||
| Round of 32 | 18/02/2021 | Sporting Braga | - | AS Roma | 0:2 | ||||
| Round of 32 | 25/02/2021 | AS Roma | - | Sporting Braga | 3:1 | ||||
| Round of 16 | 11/03/2021 | AS Roma | - | Shakhtar Donetsk | 3:0 | ||||
| Round of 16 | 18/03/2021 | Shakhtar Donetsk | - | AS Roma | 1:2 | ||||
| Quarter-finals | 08/04/2021 | AFC Ajax | - | AS Roma | 1:2 | ||||
| Quarter-finals | 15/04/2021 | AS Roma | - | AFC Ajax | 1:1 | ||||
| Semi-finals | 06/05/2021 | AS Roma | - | Manchester United | 3:2 |
Spain
