| 4. Round | 04/02/2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Round | 07/02/2021 | Boston River | - | Peñarol | 1:2 |  |
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| 6. Round | 11/02/2021 | River Plate | - | Boston River | 3:1 | ||||
| 8. Round | 19/02/2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 9. Round | 23/02/2021 | Boston River | - | Progreso | 2:3 | ||||
| 10. Round | 28/02/2021 | Fénix | - | Boston River | 2:1 | ||||
| 14. Round | 25/03/2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Round | 29/03/2021 | Boston River | - | Liverpool | 1:0 |
Uruguay
Italy