| 1. Round | 06/01/2018 | Cruz Azul | - | Club Tijuana | 0:0 | ||||
| 2. Round | 13/01/2018 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 3. Round | 21/01/2018 | CF Monterrey | - | Club Tijuana | 0:0 |  |
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| 4. Round | 27/01/2018 | Club Tijuana | - | Puebla FC | 2:0 | ||||
| 5. Round | 04/02/2018 | Santos Laguna | - | Club Tijuana | 0:0 | ||||
| 6. Round | 10/02/2018 | Club Tijuana | - | Gallos Blancos | 0:2 |  |
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| 8. Round | 18/02/2018 | Club Tijuana | - | Pumas UNAM | 4:1 | |
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| 9. Round | 25/02/2018 | CF América | - | Club Tijuana | 0:0 | |
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| 10. Round | 03/03/2018 | Club Tijuana | - | Lobos BUAP | 3:1 | ||||
| 11. Round | 11/03/2018 | UANL Tigres | - | Club Tijuana | 1:0 | ||||
| 12. Round | 17/03/2018 | Club Tijuana | - | Monarcas Morelia | 1:1 | ||||
| 13. Round | 02/04/2018 | CD Veracruz | - | Club Tijuana | 1:0 | |
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| 14. Round | 07/04/2018 | Club Tijuana | - | Atlas Guadalajara | 2:2 | ||||
| 15. Round | 14/04/2018 | Club Tijuana | - | Deportivo Guadalajara | 3:0 | |
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| 16. Round | 22/04/2018 | Club León | - | Club Tijuana | 1:1 | ||||
| 17. Round | 28/04/2018 | Club Tijuana | - | Deportivo Toluca | 1:0 |
Paraguay
Mexico