| 1. Round | 02/07/2022 | Mazatlán FC | - | Puebla FC | 2:4 | ||||
| 4. Round | 23/07/2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Round | 28/07/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 6. Round | 31/07/2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 06/08/2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 |  |
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| 8. Round | 13/08/2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 9. Round | 17/08/2022 | Mazatlán FC | - | Gallos Blancos | 1:1 | |
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| 10. Round | 21/08/2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 11. Round | 27/08/2022 | Mazatlán FC | - | CF América | 1:3 | ||||
| 13. Round | 08/09/2022 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | ||||
| 15. Round | 17/09/2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | ||||
| 16. Round | 24/09/2022 | Club Necaxa | - | Mazatlán FC | 2:2 |
Mexico