| 1. Round | 05/08/2007 | Santos Laguna | - | Cruz Azul | 2:0 | ||||
| 5. Round | 29/08/2007 | Santos Laguna | - | Deportivo Guadalajara | 2:1 | ||||
| 7. Round | 10/09/2007 | Santos Laguna | - | CF América | 4:0 | ||||
| 9. Round | 23/09/2007 | Santos Laguna | - | Puebla FC | 4:1 | ||||
| 11. Round | 07/10/2007 | Santos Laguna | - | Pumas UNAM | 3:2 | ||||
| 12. Round | 13/10/2007 | UAG Tecos | - | Santos Laguna | 3:1 |  |
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| 14. Round | 28/10/2007 | Atlas Guadalajara | - | Santos Laguna | 2:5 |  |
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| 15. Round | 01/11/2007 | Club Necaxa | - | Santos Laguna | 2:3 | |
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| 17. Round | 10/11/2007 | Club San Luis | - | Santos Laguna | 2:2 | |
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Mexico