| Group 1 | 22/08/2012 | Santos Laguna | - | CD Águila | 5:0 | ||||
| Group 1 | 29/08/2012 | Toronto FC | - | Santos Laguna | 1:3 |  |
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| Quarter-finals | 06/03/2013 | Houston Dynamo | - | Santos Laguna | 1:0 | ||||
| Quarter-finals | 14/03/2013 | Santos Laguna | - | Houston Dynamo | 3:0 | ||||
| Semi-finals | 03/04/2013 | Seattle Sounders | - | Santos Laguna | 0:1 | ||||
| Semi-finals | 10/04/2013 | Santos Laguna | - | Seattle Sounders | 1:1 | ||||
| Final | 25/04/2013 | Santos Laguna | - | CF Monterrey | 0:0 | ||||
| Final | 02/05/2013 | CF Monterrey | - | Santos Laguna | 4:2 | |
Mexico