| 2. Round | 12/09/2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 | ||||
| 3. Round | 20/09/2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 4. Round | 25/09/2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 |  |
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| 5. Round | 03/10/2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 6. Round | 17/10/2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 7. Round | 25/10/2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 9. Round | 07/11/2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | |
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| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Round | 29/11/2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 18. Round | 24/01/2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 15. Round | 10/02/2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 | ||||
| 21. Round | 14/02/2022 | Anorthosis Famagusta | - | Olympiakos Nikosia | 3:1 | ||||
| 22. Round | 26/02/2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
Greece